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Structures reveal opening of the store-operated calcium channel Orai

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The store-operated calcium (Ca2+) channel Orai governs Ca2+ influx through the plasma membrane of many non-excitable cells in metazoans. The channel opens in response to the depletion of Ca2+ stored in the endoplasmic reticulum (ER). Loss- and gain-of-function mutants of Orai cause disease. https://safeersappliancers.shop/product-category/cookers/
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