Abstract The P53-destabilizing TBC1D15-NOTCH protein interaction promotes self-renewal of tumor-initiating stem-like cells (TICs); however. the mechanisms governing the regulation of this pathway have not been fully elucidated. Here. we show that TBC1D15 stabilizes NOTCH and c-JUN through blockade of E3 ligase and CDK8 recruitment to phosphodegron sequences. https://otsportszones.shop/product-category/tie/