Abstract High-fat diet (HFD)-induced obesity is accompanied by insulin resistance and compromised brain synaptic plasticity through the impairment of insulin-sensitive pathways regulating neuronal survival. learning. and memory. Lipoic acid is known to modulate the redox status of the cell and has insulin mimetic effects. https://www.spidertattooz.com/Essie-Garden-Variety-0-5-oz-904-p15641/